3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester

Base Information

• Chemical Name: 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester
• CAS No.: 191285-50-4
• Molecular Formula: C₂₃H₃₂O₇
• Molecular Weight: 420.503
• Mol file: 191285-50-4.mol

Synonyms:3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester

Chemical Property of 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester

There total 6 articles about 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

5-(1-hydroxyhexylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (66696-79-5) + ((3aS,6R,6aS)-6-Benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-yl)-methanol (191285-49-1) → 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester (191285-50-4)

Guidance literature:

In toluene; for 2h; Heating;

DOI:10.1021/jo970461b

Reference yield:

D-Xylose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2) → 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester (191285-50-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) CuSO₄ / 1.) reflux

2: pyridine / 72 h / Ambient temperature

3: NaH / dimethylformamide / 0 - 20 °C

4: 77 percent / aq. HCl / methanol / 3 h / Ambient temperature

5: 97.6 percent / toluene / 2 h / Heating

With pyridine; hydrogenchloride; sodium hydride; copper(II) sulfate; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo970461b

Reference yield:

2,3-O-isopropylidene-β-D-threo-2-pentulofuranose (25018-68-2) → 3-Oxo-octanoic acid (3aS,6R,6aS)-6-benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-ylmethyl ester (191285-50-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 72 h / Ambient temperature

2: NaH / dimethylformamide / 0 - 20 °C

3: 77 percent / aq. HCl / methanol / 3 h / Ambient temperature

4: 97.6 percent / toluene / 2 h / Heating

With pyridine; hydrogenchloride; sodium hydride; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo970461b

upstream raw materials:

5-(1-hydroxyhexylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

((3aS,6R,6aS)-6-Benzyloxy-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-3a-yl)-methanol

D-Xylose

2,3-O-isopropylidene-β-D-threo-2-pentulofuranose