3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Base Information

Chemical Name:3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide
CAS No.:1025992-39-5
Molecular Formula:C₃₃H₄₀N₄O₃
Molecular Weight:540.706
Hs Code.:

3,3,3-triphenyl-<i>N</i>-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Synonyms:3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

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Chemical Property of 3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Chemical Property:

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Technology Process of 3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

There total 3 articles about 3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-({3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1025992-39-5
3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃;
DOI:10.1021/jm010480k

Reference yield:

: 1026399-11-0
3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid methyl ester

: 1025992-39-5
3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4N aq. NaOH / methanol; CHCl₃ / 20 °C

2: WSC; HOBt / CHCl₃ / 20 °C

3: TFA / CHCl₃ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In methanol; chloroform;
DOI:10.1021/jm010480k

Reference yield:

: 1026540-52-2
3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid

: 1025992-39-5
3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: WSC; HOBt / CHCl₃ / 20 °C

2: TFA / CHCl₃ / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In chloroform;
DOI:10.1021/jm010480k