3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid

Base Information

• Chemical Name: 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid
• CAS No.: 1026540-52-2
• Molecular Formula: C₂₇H₂₈N₂O₄
• Molecular Weight: 444.53
• Mol file: 1026540-52-2.mol

Synonyms:3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid

Chemical Property of 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid

There total 1 articles about 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid methyl ester (1026399-11-0) → 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid (1026540-52-2)

Guidance literature:

With sodium hydroxide; In methanol; chloroform; at 20 ℃;

DOI:10.1021/jm010480k

Reference yield:

1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate (140645-23-4) + 3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid (1026540-52-2) → 3-({3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃;

DOI:10.1021/jm010480k

Reference yield:

3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid (1026540-52-2) → 3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide (1025992-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: WSC; HOBt / CHCl₃ / 20 °C

2: TFA / CHCl₃ / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In chloroform;

DOI:10.1021/jm010480k

upstream raw materials:

3-[3-(3,3,3-triphenyl-propionylamino)-propionylamino]-propionic acid methyl ester

Downstream raw materials:

3,3,3-triphenyl-N-(2-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-ethyl)-propionamide