2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Base Information

Chemical Name:2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone
CAS No.:64194-76-9
Molecular Formula:C₁₉H₁₅Cl₃N₄O₂
Molecular Weight:437.713
Hs Code.:

Synonyms:2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

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Chemical Property of 2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

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Technology Process of 2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

There total 13 articles about 2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 64194-71-4
2',5-dichloro-2-<3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone dihydrobromide

: 79-04-9
chloroacetyl chloride

: 64194-76-9
2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Guidance literature:: In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00354a015

Reference yield: 48.5%

: 3-(acetylamino)-2-<(α-chloroacetamido)methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

: 64194-76-9
2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Guidance literature:: With sodium acetate; acetic acid; for 1.5h; Heating;
DOI:10.1021/jm00354a015

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 64194-76-9
2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Guidance literature:: Multi-step reaction with 5 steps

2: 17 percent / AcOH / ethanol / 6 h / Ambient temperature

4: 99 percent / 30percent HBr, AcOH / acetonitrile / 1.) RT, 1.5 h, 2.) reflux, 1 h

5: 82 percent / dimethylformamide / Ambient temperature

With hydrogen bromide; acetic acid; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00354a015