(2R)-7-benzyloxy-2-methyl-heptanoic acid

Base Information

Chemical Name:(2R)-7-benzyloxy-2-methyl-heptanoic acid
CAS No.:871733-01-6
Molecular Formula:C₁₅H₂₂O₃
Molecular Weight:250.338
Hs Code.:

Synonyms:(2R)-7-benzyloxy-2-methyl-heptanoic acid

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Chemical Property of (2R)-7-benzyloxy-2-methyl-heptanoic acid

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Technology Process of (2R)-7-benzyloxy-2-methyl-heptanoic acid

There total 10 articles about (2R)-7-benzyloxy-2-methyl-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 871732-91-1
[(2'R),4R]-3-(7-benzyloxy-2-methyl-1-oxoheptyl)-4-benzyl-2-oxazolidinone

: 871733-01-6
(2R)-7-benzyloxy-2-methyl-heptanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 871733-01-6
(2R)-7-benzyloxy-2-methyl-heptanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 83 percent / sodium hydride / various solvent(s) / cooling

2.1: 81 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - -60 °C

3.1: 91 percent / CH₂Cl₂ / 0 - 20 °C

4.1: 77 percent / Na₂CO₃; hydrogen / Pd/C / 4 h

5.1: 89 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

6.1: oxalyl chloride; DMF / CH₂Cl₂ / 0 °C

7.1: 84.9 percent / DMAP; triethylamine / CH₂Cl₂ / 12 h / 20 °C

8.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

8.2: 87 percent / tetrahydrofuran / 4 h / -78 °C

9.1: 91 percent / hydrogen peroxide; LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

With dmap; lithium hydroxide; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 2.1: Swern oxidation;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: 4541-15-5
5-(benzyloxy)-1-pentanol

: 871733-01-6
(2R)-7-benzyloxy-2-methyl-heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 81 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - -60 °C

2.1: 91 percent / CH₂Cl₂ / 0 - 20 °C

3.1: 77 percent / Na₂CO₃; hydrogen / Pd/C / 4 h

4.1: 89 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

5.1: oxalyl chloride; DMF / CH₂Cl₂ / 0 °C

6.1: 84.9 percent / DMAP; triethylamine / CH₂Cl₂ / 12 h / 20 °C

7.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

7.2: 87 percent / tetrahydrofuran / 4 h / -78 °C

8.1: 91 percent / hydrogen peroxide; LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

With dmap; lithium hydroxide; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; sodium carbonate; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 1.1: Swern oxidation;
DOI:10.1016/j.tet.2005.09.040