tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate

Base Information

• Chemical Name: tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate
• CAS No.: 1394134-30-5
• Molecular Formula: C₂₉H₄₅N₃O₃
• Molecular Weight: 483.695
• Mol file: 1394134-30-5.mol

Synonyms:tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate

Chemical Property of tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate

There total 8 articles about tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H20N2O (76272-57-6) + -5-<<(1,1-dimethylethoxy)carbonyl>amino>-7-methyl-3-octenoic acid (91465-67-7) → tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate (1394134-30-5)

Guidance literature:

C₁₅H₂₀N₂O; With methanol; sodium tetrahydroborate; nickel dichloride; In water; at -15 - 20 ℃; for 2.5h; Inert atmosphere;

-5-<<(1,1-dimethylethoxy)carbonyl>amino>-7-methyl-3-octenoic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

-5-<<(1,1-dimethylethoxy)carbonyl>amino>-7-methyl-3-octenoic acid (91465-67-7) + (±)-(1R,3r,5S)-9-benzyl-9-azabicyclo[3.3.1]nonan-3-yl acetate (76272-58-7) → tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate (1394134-30-5)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c3ob40489g

Reference yield:

Glutaraldehyde (111-30-8,29257-65-6,79215-57-9) → tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate (1394134-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 60 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / Reflux

3.1: sodium tetrahydroborate; nickel dichloride; methanol / water / 2.5 h / -15 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydroxide; nickel dichloride; In ethanol; water;

upstream raw materials:

Glutaraldehyde

benzylamine

9-benzyl-9-azabicyclo[3.3.1]nonan-3-one

C₁₅H₂₀N₂O