76272-58-7

Upstream product

• 111-30-8 Glutaraldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 142894-63-1 1H-Indole-3-carboxylic acid ((1R,3R,5S)-9-benzyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide 
• 142894-64-2 1-Methyl-1H-indole-3-carboxylic acid ((1R,3R,5S)-9-benzyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide 
• 1210745-16-6 N-[(3-endo)-9-(phenylmethyl)-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide 
• 1394134-30-5 tert-butyl (S,E)-8-(9-benzyl-9-azabicyclo[3.3.1]nonan-3-ylamino)-2-methyl-8-oxooct-5-en-4-ylcarbamate 
• 153431-10-8 3β-<(tert-butyloxycarbonyl)amino>-9-benzyl-9-azabicyclo<3.3.1>nonane 
• 155560-04-6 tert-butyl-9-azabicyclo[3.3.1]nonan-3-ylcarbamate 
• 160177-67-3 endo-N-(9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide 
• 128395-47-1 1-methyl-N-[(3-endo)-9-(phenylmethyl)-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide 

Relevant academic research and scientific papers

Predicting Electrocatalytic Properties: Modeling Structure-Activity Relationships of Nitroxyl Radicals

Stable nitroxyl radical-containing compounds, such as 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and its derivatives, are capable of electrocatalytically oxidizing a wide range of alcohols under mild and environmentally friendly conditions. Herein, we examine the structure-function relationships that determine the catalytic activity of a diverse range of water-soluble nitroxyl radical compounds. A strong correlation is described between the difference in the electrochemical oxidation potentials of a compound and its electrocatalytic activity. Additionally, we construct a simple computational model that is able to accurately predict the electrochemical potential and catalytic activity of a wide range of nitroxyl radical derivatives.

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.

Toward biophysical probes for the 5-HT3 receptor: Structure-activity relationship study of granisetron derivatives

This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT3A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identification of positions on the granisetron core that might be used as attachment points for biophysical tags. A BODIPY fluorophore was appended to one such position and specifically bound to 5-HT3A receptors in mammalian cells.

NEW COMPOUNDS

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.