(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate
• CAS No.: 335395-11-4
• Molecular Formula: C₁₇H₂₃Cl₂NO₄
• Molecular Weight: 376.28

Synonyms:(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate

Chemical Property of (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate

There total 2 articles about (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-vinylmorpholine-4-carboxylate (1239279-23-2) → (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate (335395-11-4)

Guidance literature:

(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-vinylmorpholine-4-carboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 4h;

With dihydrogen peroxide; sodium hydroxide;

DOI:10.1021/jo102471r

Reference yield:

C19H30BCl2NO3S → (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate (335395-11-4)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1021/ol101555g

Reference yield: 67.0%

(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate (335395-11-4) → (R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol (191673-56-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol101555g

upstream raw materials:

(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-vinylmorpholine-4-carboxylate

Downstream raw materials:

(R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol

(R)-(2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholino)(phenyl)methanone

SSR 241586

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