2-[2-(3,4-Dichlorophenyl)morpholin-2-YL]ethanol

Base Information

• Chemical Name: 2-[2-(3,4-Dichlorophenyl)morpholin-2-YL]ethanol
• CAS No.: 191673-56-0
• Molecular Formula: C12H15 Cl2 N O2
• Molecular Weight: 276.163
• DSSTox Substance ID: DTXSID10573093
• Nikkaji Number: J1.282.625G
• Mol file: 191673-56-0.mol

Synonyms:2-[2-(3,4-DICHLOROPHENYL)MORPHOLIN-2-YL]ETHANOL;191673-56-0;SCHEMBL3978164;DTXSID10573093;WNVVRSBOQUEIFR-UHFFFAOYSA-N;2-[2-(3,4-Dichlorophenyl)morpholin-2-yl]ethan-1-ol

Chemical Property of 2-[2-(3,4-Dichlorophenyl)morpholin-2-YL]ethanol

Chemical Property:

• Vapor Pressure: 1.18E-07mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 415.6°Cat760mmHg
• Flash Point: 205.2°C
• PSA: 41.49000
• Density: 1.283g/cm³
• LogP: 2.51970
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 275.0479841
• Heavy Atom Count: 17
• Complexity: 255

Purity/Quality:

98% ^*data from raw suppliers

2-[2-(3,4-DICHLOROPHENYL)MORPHOLIN-2-YL]ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)(CCO)C2=CC(=C(C=C2)Cl)Cl

Technology Process of 2-[2-(3,4-Dichlorophenyl)morpholin-2-YL]ethanol

There total 22 articles about 2-[2-(3,4-Dichlorophenyl)morpholin-2-YL]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether (191673-60-6) → (R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol (191673-56-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 3h;

DOI:10.1016/S0957-4166(98)00336-X

Reference yield: 67.0%

(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine-4-carboxylate (335395-11-4) → (R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol (191673-56-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol101555g

Reference yield:

2-[(2 R)-(3,4-dichlorophenyl)-5-oxomorpholin-2-yl]ethanol t-butyldimethylsilyl ether → (R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol (191673-56-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium chloride; In tetrahydrofuran;

upstream raw materials:

2-[4-t-Butoxycarbonyl-(2 R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether

2-(3,4-Dichlorophenyl)-2-(2-hydroxyethyl)morpholine

2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-(3,4-dichloro-phenyl)-morpholine

tert-Butyl-[3-(3,4-dichloro-phenyl)-but-3-enyloxy]-dimethyl-silane

Downstream raw materials:

(2R)-2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol

2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethanol

(2R)-2-[4-{[3,5-bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)morpholin-2-yl]ethanol

(R)-(2-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholino)(phenyl)methanone

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