3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

Base Information

Chemical Name:3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone
CAS No.:893408-47-4
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:

Synonyms:3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

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Chemical Property of 3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

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Technology Process of 3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

There total 11 articles about 3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 893408-51-0
3-acetyl-1,4-dihydroxy-5-(4-benzyloxy-3,5-diisopropylphenyl)-2(1H)-pyridone

: 893408-47-4
3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/j.tet.2006.01.090

Reference yield:

: 893408-44-1
2-(benzyloxy)-5-bromo-1,3-diisopropylbenzene

: 893408-47-4
3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / tetrahydrofuran; hexane / 1 h / 25 °C

1.2: 50 percent / trimethyl borate / tetrahydrofuran; hexane / 25 °C

2.1: 71 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / 12 h / Heating

3.1: H₂ / Pd/C / dioxane / 2 h / 25 °C

4.1: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / -78 °C

With hydrogen; tert.-butyl lithium; boron tribromide; sodium carbonate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; toluene; 2.1: Suzuki reaction;
DOI:10.1016/j.tet.2006.01.090

Reference yield:

: 893408-45-2
4-benzyloxy-3,5-diisopropylphenylboronic acid

: 893408-47-4
3-acetyl-1,4-dihydroxy-5-(3,5-diisopropyl-4-hydroxyphenyl)-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / 12 h / Heating

2: H₂ / Pd/C / dioxane / 2 h / 25 °C

3: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / -78 °C

With hydrogen; boron tribromide; sodium carbonate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; toluene; 1: Suzuki reaction;
DOI:10.1016/j.tet.2006.01.090