N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide
CAS No.:582295-69-0
Molecular Formula:C₅₁H₆₁N₅O₈Si
Molecular Weight:900.16
Hs Code.:

<i>N</i>-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-4-yl)-9<i>H</i>-purin-6-yl]-benzamide

Synonyms:N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

There total 4 articles about N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 582295-68-9
N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

: 582295-69-0
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 50 ℃;
DOI:10.1039/b300932g

Reference yield:

: 39947-04-1
N-6-benzoyl-2',3'-O-isopropylideneadenosine

: 582295-69-0
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 1H-imidazole; DMAP / CH₂Cl₂ / 3 h / 23 °C

2: 94 percent / EtNiPr₂; DMAP / CH₂Cl₂ / 3 h / 50 °C

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.200490204

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 582295-69-0
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 1H-imidazole; DMAP / CH₂Cl₂ / 3 h / 23 °C

2: 94 percent / EtNiPr₂; DMAP / CH₂Cl₂ / 3 h / 50 °C

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.200490204