Toloxatone

Base Information

Chemical Name:Toloxatone
CAS No.:29218-27-7
Molecular Formula:C11H13 N O3
Molecular Weight:207.229
Hs Code.:
European Community (EC) Number:249-522-2
UNII:5T206015T5
DSSTox Substance ID:DTXSID40865478
Nikkaji Number:J21.701H
Wikipedia:Toloxatone
Wikidata:Q3530618
NCI Thesaurus Code:C97715
Pharos Ligand ID:SXN6TSNX3S16
Metabolomics Workbench ID:144608
ChEMBL ID:CHEMBL18116
Mol file:29218-27-7.mol

Synonyms:(3-methyl)-3-phenyl-5-hydroxymethyl-2-oxazolidinone;toloxatone

Suppliers and Price of Toloxatone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Toloxatone
10mg
$ 340.00

TRC
Toloxatone
250mg
$ 1865.00

Sigma-Aldrich
Toloxatone ≥98% (HPLC), solid
10mg
$ 100.00

Sigma-Aldrich
Toloxatone ≥98% (HPLC), solid
50mg
$ 449.00

DC Chemicals
Toloxatone(MD69276) >98%
1 g
$ 1350.00

DC Chemicals
Toloxatone(MD69276) >98%
100 mg
$ 400.00

CSNpharm
Toloxatone
25mg
$ 195.00

CSNpharm
Toloxatone
1g
$ 960.00

Crysdot
Toloxatone 97%
1g
$ 1186.00

ChemScene
Toloxatone 99.34%
5mg
$ 60.00

Total 30 raw suppliers

Chemical Property of Toloxatone

Chemical Property:

Vapor Pressure:8.9E-06mmHg at 25°C
Melting Point:76°
Boiling Point:358.9°Cat760mmHg
Flash Point:170.9°C
Density:1.245g/cm³
Storage Temp.:2-8°C
Solubility.:DMSO: >10mg/mL
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:207.08954328
Heavy Atom Count:15
Complexity:244

Purity/Quality:

99%, ^*data from raw suppliers

Toloxatone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)N2CC(OC2=O)CO
Description Toloxatone is a selective, reversible and competitive inhibitor of type A monoamine oxidase (MAO-A) which shows clinical utility as an antidepressant. It is reportedly free of the "cheese effect" in man, possibly due to the reversible nature of its inhibitory effect on intestinal MAO-A in the presence of high concentrations of tyramine.
Uses Toloxatone is a monoamine oxidase-A (MAO-A) inhibitor.

Technology Process of Toloxatone

There total 22 articles about Toloxatone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5-(bromomethyl)-3-m-tolyloxazolidin-2-one

: 29218-27-7
toloxatone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tet.2017.04.063

Reference yield: 82.0%

: 625-95-6
3-Iodotoluene

: 7517-99-9
5-hydroxymethyl-2-oxazolidinone

: 29218-27-7
toloxatone

: 57558-39-1
5-m-tolyloxymethyl-oxazolidin-2-one

Guidance literature:: With potassium phosphate; copper(l) iodide; (+/-)-trans-cyclohexanediamine; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.3987/COM-03-S7

Reference yield: 79.0%

: 124-38-9,18923-20-1
carbon dioxide

: 3-methyl-N-(oxiran-2-ylmethyl)aniline

: 29218-27-7
toloxatone

Guidance literature:: With dmap; C₂₀H₁₄AlNO₃; In dichloromethane; at 25 ℃; for 24h; under 760.051 Torr; Sealed tube;
DOI:10.1021/acs.orglett.8b02186