7517-99-9

Basic information

• Product Name: 5-(Hydroxymethyl)-1,3-oxazolidin-2-one
• Synonyms: 5-(HydroxyMethyl)oxazolidin-2-one;5-(hydroxymethyl)-2-Oxazolidinone;5-(Hydroxymethyl)-1,3-oxazolidin-2-one
• CAS NO: 7517-99-9
• Molecular Formula: C₄H₇NO₃
• Molecular Weight: 117
• Mol File: 7517-99-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 56.8 °C
• Boiling Point: 430.6±14.0 °C(Predicted)
• Appearance: /
• Density: 1.288±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.33±0.40(Predicted)
• CAS DataBase Reference: 5-(Hydroxymethyl)-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Hydroxymethyl)-1,3-oxazolidin-2-one(7517-99-9)
• EPA Substance Registry System: 5-(Hydroxymethyl)-1,3-oxazolidin-2-one(7517-99-9)

Safety Data

• Hazardous Substances Data: 7517-99-9(Hazardous Substances Data)

Usage

General Description

5-(Hydroxymethyl)-1,3-oxazolidin-2-one, also known as glycidic acid, is a heterocyclic organic compound with a cyclic structure containing oxygen and nitrogen atoms. It is a white crystalline solid, and it is commonly used as a monomer in the synthesis of polymeric materials. This chemical compound is also a key intermediate in the production of various pharmaceuticals and agrochemicals. It has been studied for its potential as a building block for biodegradable polymers and drug delivery systems due to its biocompatibility and low toxicity. Overall, 5-(Hydroxymethyl)-1,3-oxazolidin-2-one has a wide range of applications in the fields of chemistry, materials science, and pharmaceuticals.

Upstream product

• 330555-60-7 (S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one 
• 56-81-5 glycerol 
• 57-13-6 urea 
• 852805-35-7 (S)-5-(4-methoxyphenoxymethyl)-1,3-oxazolidin-2-one 
• 61278-21-5 (S)-3-Amino-1,2-propanediol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 105-58-8 Diethyl carbonate 
• 112663-80-6 (S)-2-oxazolidinone-5-carboxylic acid benzyl ester 
• 113420-80-7 Acetic acid (S)-2-oxo-oxazolidin-5-ylmethyl ester 

Downstream Products

• 7517-99-9 (S)-5-(hydroxymethyl)-1,3-oxazolidin-2-one 
• 97859-49-9 (R)-5-(hydroxymethyl)-1,3-oxazolidin-2-one 
• 29218-27-7 toloxatone 
• 1369530-77-7 3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one 
• 1222521-08-5 5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)oxazolidin-2-one 
• 513068-96-7 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one 
• 109794-68-5 (S)-(2-oxo-1,3-oxazolidin-5-yl)methyl 4-methylbenzenesulfonate 
• 57558-39-1 5-m-tolyloxymethyl-oxazolidin-2-one 
• 29218-21-1 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine 
• 97899-38-2 (2-oxo-1,3-oxazolidin-5-yl)-methyl 4-methylbenzenesulfonate 

Relevant articles and documents

QUINAZOLINE COMPOUND FOR EGFR INHIBITION

Disclosed is a novel quinazoline compound. Specifically, disclosed are a compound represented by the formula (I) and a pharmacologically acceptable salt.

Heterometallic metal-organic framework-templated synthesis of porous Co3O4/ZnO nanocage catalysts for the carbonylation of glycerol

The efficient synthesis of glycerol carbonate (GLC) has recently received great attention due to its significance in reducing excess glycerol in biodiesel production as well as its promising applications in several industrial fields. However, the achievement of high conversion and high selectivity of GLC from glycerol in heterogeneous catalytic processes remains a challenge due to the absence of high-performance solid catalysts. Herein, highly porous nanocage catalysts composed of well-mixed Co3O4 and ZnO nanocrystals were successfully fabricated via a facile heterometallic metal-organic framework (MOF)-templated synthetic route. Benefiting from a high porosity and the synergistic effect between Co3O4 and ZnO, the as-prepared composite catalysts exhibited a significantly enhanced production efficiency of GLC in the carbonylation reaction of glycerol with urea compared to the single-component counterparts. The yield of GLC over the Co50Zn50-350 catalyst reached 85.2%, with 93.3% conversion and near 91% GLC selectivity, and this catalytic performance was superior to that over most heterogeneous catalysts. More importantly, the proposed templated synthetic strategy of heterometallic MOFs facilitates the regulation of catalyst composition and surface structure and can therefore be potentially extended in the tailoring of other metal oxide composite catalysts.

Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera