3-{[(2S)-3-(biphenyl-4-yl)-2-{[(diphenoxyphosphoryl)methyl]amino}propanoyl]amino}propanoic acid (non-preferred name)

Base Information

• Chemical Name: 3-{[(2S)-3-(biphenyl-4-yl)-2-{[(diphenoxyphosphoryl)methyl]amino}propanoyl]amino}propanoic acid (non-preferred name)
• CAS No.: 147862-03-1
• Molecular Formula: C31H31 N2 O6 P
• Molecular Weight: 558.571
• Mol file: 147862-03-1.mol

Synonyms:b-Alanine,N-[3-[1,1'-biphenyl]-4-yl-N-[(diphenoxyphosphinyl)methyl]-L-alanyl]-; CGS 25462

Chemical Property of 3-{[(2S)-3-(biphenyl-4-yl)-2-{[(diphenoxyphosphoryl)methyl]amino}propanoyl]amino}propanoic acid (non-preferred name)

Chemical Property:

• Vapor Pressure: 5.99E-26mmHg at 25°C
• Boiling Point: 784.9°C at 760 mmHg
• Flash Point: 428.5°C
• Density: 1.267g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-{[(2S)-3-(biphenyl-4-yl)-2-{[(diphenoxyphosphoryl)methyl]amino}propanoyl]amino}propanoic acid (non-preferred name)

There total 3 articles about 3-{[(2S)-3-(biphenyl-4-yl)-2-{[(diphenoxyphosphoryl)methyl]amino}propanoyl]amino}propanoic acid (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

benzyl (S)-N-[2-(diphenylphosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionate (147862-02-0) → CGS 25462 (147862-03-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 5.5h; under 2585.7 Torr;

Reference yield:

diphenyl hydrogen phosphite (4712-55-4) → CGS 25462 (147862-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.7 percent / toluene / 1.25 h / 70 °C

2: 67 percent / H₂ / 10percent Pd/C / ethyl acetate / 5.5 h / 2585.7 Torr

With hydrogen; palladium on activated charcoal; In ethyl acetate; toluene;

Reference yield:

1,3,5-tris<(S)-1-(1-O-benzyl-β-alaninyl)-3-(4-biphenylyl)-1-oxo-2-propyl>hexahydro-1,3,5-triazine (147862-25-7) → CGS 25462 (147862-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.7 percent / toluene / 1.25 h / 70 °C

2: 67 percent / H₂ / 10percent Pd/C / ethyl acetate / 5.5 h / 2585.7 Torr

With hydrogen; palladium on activated charcoal; In ethyl acetate; toluene;

upstream raw materials:

benzyl (S)-N-[2-(diphenylphosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionate

diphenyl hydrogen phosphite

1,3,5-tris<(S)-1-(1-O-benzyl-β-alaninyl)-3-(4-biphenylyl)-1-oxo-2-propyl>hexahydro-1,3,5-triazine

Downstream raw materials:

5-indanyl (S)-N-[2-(diphenylphosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionate

3-{(S)-3-Biphenyl-4-yl-2-[(diphenoxy-phosphorylmethyl)-amino]-propionylamino}-propionic acid ethyl ester

N,N-diethylcarbamoylmethyl (S)-N-[2-(diphenylphosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionate

3-{(S)-3-Biphenyl-4-yl-2-[(diphenoxy-phosphorylmethyl)-amino]-propionylamino}-propionic acid (diisopropylcarbamoyl)-methyl ester

Refernces

• 1、 -. "Phosphono/biaryl substituted dipetide derivatives". . . Retrieved 2008/06/13.