tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

Base Information

Chemical Name:tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate
CAS No.:1379445-65-4
Molecular Formula:C₁₈H₂₁N₃O₄S
Molecular Weight:375.448
Hs Code.:

Synonyms:tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

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Chemical Property of tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

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Technology Process of tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

There total 4 articles about tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1082827-81-3
(3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 1379445-65-4
tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

Guidance literature:: (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

p-cyanobenzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1379445-65-4
tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / hexane; tetrahydrofuran / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrazine hydrate / acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

3.2: 20 °C

With sodium hydride; hydrazine hydrate; In tetrahydrofuran; hexane; acetic acid; mineral oil;

Reference yield:

: 116423-03-1
tert-butyl 3-acetyl-4-oxopentanoate

: 1379445-65-4
tert-butyl {1-[(4-cyanophenyl)sulfonyl]-3,5-dimethyl-1H-pyrazol-4-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / acetic acid / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 20 °C

With sodium hydride; hydrazine hydrate; In tetrahydrofuran; acetic acid; mineral oil;