Technology Process of diethyl α,α-bromofluoro-4-nitrobenzylphosphonate
There total 3 articles about diethyl α,α-bromofluoro-4-nitrobenzylphosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl α-bromo-4-nitrobenzylphosphonate;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1.16667h;
Inert atmosphere;
With
N-fluorobis(benzenesulfon)imide;
In
tetrahydrofuran;
at -78 ℃;
for 2.16667h;
Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.06.016
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 8 h / Reflux
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere
2.2: 2.17 h / -78 °C / Inert atmosphere
With
tetrabutylammomium bromide; sodium hexamethyldisilazane; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.jfluchem.2011.06.016
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium ethanolate / dichloromethane / -35 °C / Inert atmosphere
1.2: -35 °C / Inert atmosphere
2.1: tetrabutylammomium bromide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 8 h / Reflux
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere
3.2: 2.17 h / -78 °C / Inert atmosphere
With
tetrabutylammomium bromide; sodium ethanolate; sodium hexamethyldisilazane; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.jfluchem.2011.06.016
