N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

Base Information

Chemical Name:N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide
CAS No.:73972-05-1
Molecular Formula:C₁₆H₁₇NO₂
Molecular Weight:255.316
Hs Code.:

Synonyms:N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

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Technology Process of N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

There total 8 articles about N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 73972-04-0
N-[2-(7-Oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

: 74-88-4
methyl iodide

: 73972-05-1
N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1) 1h -23 deg C 2) 1h 0 deg C 3) 2h room temperature;
DOI:10.1021/jo01304a002

Reference yield:

: 21802-85-7
2-(cyclohexa-1,4-dien-1-yl)ethan-1-amine

: 73972-05-1
N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / toluene / 1) 1h ambient temperature 2) 1h reflux

2: 53 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / Heating

3: 76 percent / bromine / CH₂Cl₂ / 2.5 h / -78 °C

4: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature

5: 51 percent / anhydrous hydrazine / CH₂Cl₂ / 24 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 1) ice bath 2) 25 min room temperature

7: 89 percent / NaH / dimethylformamide / 1) 1h -23 deg C 2) 1h 0 deg C 3) 2h room temperature

With bromine; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo01304a002

Reference yield:

: 73971-96-7
1-(β-Aminoethyl)benzene Oxide

: 73972-05-1
N-Methyl-N-[2-(7-oxa-bicyclo[4.1.0]hepta-2,4-dien-1-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1) ice bath 2) 25 min room temperature

2: 89 percent / NaH / dimethylformamide / 1) 1h -23 deg C 2) 1h 0 deg C 3) 2h room temperature

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo01304a002