4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

Base Information

Chemical Name:4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile
CAS No.:1360628-84-7
Molecular Formula:C₂₅H₂₀FN₅O₃S
Molecular Weight:489.53
Hs Code.:

Synonyms:4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

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Chemical Property of 4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

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Technology Process of 4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

There total 8 articles about 4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-trimethylsilanylethyl {2-[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yloxy]-2-thiophen-2-ylethyl}carbamate

: 1360628-84-7
4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

Guidance literature:: With cesium fluoride; In dimethyl sulfoxide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1360628-61-0
4-(8-benzyloxy-7-methoxy-2-oxo-2,3-dihydroimidazo-[4,5-c]quinolin-1-yl)-3-fluorobenzonitrile

: 1360628-84-7
4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

3: di-isopropyl azodicarboxylate; 2-(diphenylphosphino)pyridine / tetrahydrofuran / 0.25 h / 20 °C

4: cesium fluoride / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate; boron tribromide; potassium carbonate; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1360628-99-4
4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

: 1360628-84-7
4-[8-(2-amino-1-thiophen-2-ylethoxy)-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

4: di-isopropyl azodicarboxylate; 2-(diphenylphosphino)pyridine / tetrahydrofuran / 0.25 h / 20 °C

5: cesium fluoride / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;