N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

Base Information

Chemical Name:N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine
CAS No.:1429373-13-6
Molecular Formula:C₂₆H₃₅N₃O₇S
Molecular Weight:533.646
Hs Code.:

Synonyms:N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

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Chemical Property of N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

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Technology Process of N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

There total 2 articles about N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1207560-58-4
4-(ethoxycarbonyl)-3-ethyl-2-(2-nitroethyl)pyrrole

: 1429373-12-5
1-(N-tosylpiperidin-4-ylidene)propan-2-one

: 1429373-13-6
N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c3nj41161c

Reference yield:

: 33439-27-9
N-tosyl-4-piperidone

: 1429373-13-6
N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 72 h / 5 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; In ethanol; acetonitrile; 2: |Michael Addition;
DOI:10.1039/c3nj41161c

Reference yield: 13.0%

: 1429373-13-6
N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine

: 2H-spiro[8-carboethoxy-7-ethyl-1-methyldipyrrin-3,4'-N-tosylpiperidine]

: 1429373-30-7
1-(N-tosyl-1,2,3,6-tetrahydropyridin-4-yl)propan-2-one

Guidance literature:: N-tosyl-4-[2-(4-ethoxycarbonyl-3-ethylpyrrol-2-yl)-1-nitroethyl]-4-(2-oxopropyl)piperidine; With sodium methylate; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

With hydrogenchloride; titanium(III) chloride; ammonium acetate; In water; at 20 ℃; for 16h; pH=6; Inert atmosphere;
DOI:10.1039/c3nj41161c