2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

Base Information

Chemical Name:2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide
CAS No.:388075-01-2
Molecular Formula:C₁₇H₂₇F₂N₃O₂
Molecular Weight:343.417
Hs Code.:

2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-<i>N</i>-isobutyl-propionamide

Synonyms:2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

Chemical Property:

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Technology Process of 2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

There total 3 articles about 2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388073-71-0
(1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(S)-(1-isobutylcarbamoyl-ethylamino)-propyl]-carbamic acid tert-butyl ester

: 388075-01-2
2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm061242y

Reference yield:

: 388071-27-0
tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

: 388075-01-2
2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / silica gel / CH₂Cl₂ / 72 h / 20 °C

2: TFA / CH₂Cl₂ / 3 h / 0 °C

With silica gel; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm061242y

Reference yield:

: 84914-65-8
L-alanine isobutylamide

: 388075-01-2
2-[3-amino-4-(3,5-difluoro-phenyl)-2-hydroxy-butylamino]-N-isobutyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / silica gel / CH₂Cl₂ / 72 h / 20 °C

2: TFA / CH₂Cl₂ / 3 h / 0 °C

With silica gel; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm061242y