388071-27-0

Basic information

• Product Name: ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE
• Synonyms: ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE;tert-butyl (S)-2-(3,5-difluorophenyl)-1-((S)-oxiran-2-yl)ethylcarbaMate;[(1S)-2-(3,5-Difluorophenyl)-1-((2S)-oxiran-2-yl)ethyl]carbamic acid tert-butyl ester;[(1S)-2-(3,5-Difluorophenyl)-1-((2S)-oxiranyl)ethyl]carbamic acid tert-butyl ester;tert-Butyl [(1S)-2-(3,5-difluorophenyl)-1-((2S)-oxiran-2-yl)ethyl]carbamate;tert-Butyl [(1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethyl]carbamate;(1S)-2-(3,5-Difluorophenyl)-1-[(2S)-oxiran-2-yl]ethyl N-tert-butylcarbamate;erythro-N-Boc-L-3,5-difluorophenylalanine epoxide≥ 99% (HPLC)
• CAS NO: 388071-27-0
• Molecular Formula: C₁₅H₁₉F₂NO₃
• Molecular Weight: 299.31
• Product Categories: Chiral Amino Epoxides
• Mol File: 388071-27-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 390.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.227
• PKA: 11.85±0.46(Predicted)
• CAS DataBase Reference: ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE(388071-27-0)
• EPA Substance Registry System: ERYTHRO-N-BOC-L-3,5-DIFLUOROPHENYLALANINE EPOXIDE(388071-27-0)

Safety Data

• Hazardous Substances Data: 388071-27-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 531521-48-9 (2S,3S)-3-amino-4-(3,5-difluorophenyl)butane-1,2-diol 
• 877078-49-4 (S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one 
• 531521-49-0 tert-butyl [(2S,3S)-1-(3,5-difluorophenyl)-3,4-dihydroxybutan-2-yl]carbamate 
• 84315-24-2 3-(3,5-difluorophenyl)propionic acid 
• 205445-52-9 (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,5-difluorophenyl)propanoic acid 
• 388071-25-8 tert-butyl (1S)-3-bromo-1-(3,5-difluorobenzyl)-2-oxopropylcarbamate 
• 1361944-83-3 C₁₅H₁₉F₂NO₃ 
• 362480-01-1 (S)-tert-butyl 3-(3,5-difluorophenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate 
• 388072-80-8 [(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-chloro-propyl]carbamic acid t-butyl ester 

Downstream Products

• 676134-94-4 tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isopropylphenyl)cyclohexyl]amino}propylcarbamate 
• 676138-35-5 tert-butyl (1S,2R)-3-{[1-(3-bromophenyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate 
• 861857-84-3 [3-[1-(3-tert-butyl-5-iodo-phenyl)-cyclohexylamino]-(1S,2R)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 1221424-61-8 C₃₁H₄₄F₂N₂O₃ 
• 1108698-57-2 tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]carbamate 
• 388071-80-5 (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-methoxybenzylamino)propyl]-carbamic acid tert-butyl ester 
• 1448783-75-2 C₂₈H₃₅F₂N₃O₃ 
• 1448783-74-1 C₂₆H₃₂F₄N₂O₃ 
• 1448783-72-9 C₂₈H₃₆F₂N₂O₄ 
• 1448783-65-0 C₂₆H₃₂F₂N₂O₄ 
• 1448783-64-9 C₂₆H₃₂F₄N₂O₃ 
• 1448783-63-8 C₂₆H₃₁F₂N₃O₃ 

Relevant articles and documents

Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors

Enantioselective syntheses of tert-butyl ((S)-2-(3,5-difluorophenyl)-1-((S)-oxiran-2-yl)ethyl)carbamate and ((S)-2-(3,5-difluorophenyl)-1-((R)-oxiran-2-yl)ethyl)carbamate are described. We utilized asymmetric syn- and anti-aldol reactions to set both ster

BETA-SECRETASE INHIBITING COMPOUNDS

Disclosed are compounds represented by Formula (I) as defined in the specification, or pharmaceutically acceptable salts or isomers thereof, and a pharmaceutical composition for inhibiting beta-secretase activity comprising a therapeutically effective amount of the same.

Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.