N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide

Base Information

• Chemical Name: N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide
• CAS No.: 890657-53-1
• Molecular Formula: C₂₀H₂₅N₃O
• Molecular Weight: 323.438
• Mol file: 890657-53-1.mol

Synonyms:N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide

Chemical Property of N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide

There total 2 articles about N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8) + carbon monoxide (201230-82-2) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide (890657-53-1)

Guidance literature:

With potassium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; Palladacycle; In 1,4-dioxane; at 120 ℃; for 12h; under 6000.6 Torr;

Reference yield: 87.0%

→ N-(4-methylphenyl)-4-(4-methylpiperazinyl-1-methyl)benzamide (890657-53-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

carbon monoxide

p-toluidine