di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Base Information

Chemical Name:di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate
CAS No.:1357575-45-1
Molecular Formula:C₆₂H₈₄ClF₃N₄O₁₄P₂S₃
Molecular Weight:1359.96
Hs Code.:

di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Synonyms:di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

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Chemical Property of di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

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Technology Process of di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

There total 14 articles about di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1357575-28-0
(R)-4-(4-((4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoic acid

: 1357575-43-9
(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

: 1357575-45-1
di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 18 - 25 ℃; for 72h;

Reference yield:

: 1357575-41-7
benzyl bis(2-(di-tert-butoxyphosphoryloxy)ethyl)carbamate

: 1357575-45-1
di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h

2: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 18 - 25 °C

3: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 18 - 25 °C

With dmap; hydrogen; sodium tris(acetoxy)borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 5%-palladium/activated carbon; In methanol; dichloromethane;

Reference yield:

: 583-53-9
2,3-dibromobenzene

: 1357575-45-1
di-tert-butyl 2,2'-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / Inert atmosphere; Reflux

2.1: TurboGrignard / tetrahydrofuran / -15 - 25 °C / Inert atmosphere

2.2: 1.58 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane; methanol / 0.67 h / 18 - 25 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 h / 120 °C

4.2: 24 h / 120 °C

5.1: Chiralpak IA column / isopropyl alcohol / Resolution of racemate

6.1: water / tetrahydrofuran; methanol / 50 °C

6.2: pH ~ 5

7.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 18 - 25 °C

With dmap; TurboGrignard; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene; 1.1: Suzuki Coupling;