(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Base Information

Chemical Name:(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate
CAS No.:1357575-43-9
Molecular Formula:C₃₇H₆₂F₃N₃O₁₂P₂S₃
Molecular Weight:956.053
Hs Code.:

Synonyms:(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

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Chemical Property of (R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

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Technology Process of (R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

There total 7 articles about (R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1357575-44-0
(R)-4-((4-oxo-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

: 1357575-42-8
2,2'-azanediylbis(ethane-2,1-diyl) di-tert-butyl diphosphate

: 1357575-43-9
(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 18 - 25 ℃; for 1h;

Reference yield:

: 1357575-41-7
benzyl bis(2-(di-tert-butoxyphosphoryloxy)ethyl)carbamate

: 1357575-43-9
(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h

2: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 18 - 25 °C

With hydrogen; sodium tris(acetoxy)borohydride; 5%-palladium/activated carbon; In methanol; dichloromethane;

Reference yield:

: 1027345-08-9
4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

: 1357575-43-9
(R)-di-tert-butyl 2,2'-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butylazanediyl)bis(ethane-2,1-diyl)diphosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 50 °C

2.1: diisobutylaluminium hydride / dichloromethane; n-heptane / 3 h / -78 °C

2.2: -78 - 25 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 18 - 25 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In n-heptane; dichloromethane; N,N-dimethyl-formamide;