rac-1-methyl-3-phenyl-piperidin-3-ylamine

Base Information

Chemical Name:rac-1-methyl-3-phenyl-piperidin-3-ylamine
CAS No.:1236302-33-2
Molecular Formula:C₁₂H₁₈N₂
Molecular Weight:190.288
Hs Code.:

Synonyms:rac-1-methyl-3-phenyl-piperidin-3-ylamine

Suppliers and Price of rac-1-methyl-3-phenyl-piperidin-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-1-methyl-3-phenyl-piperidin-3-ylamine

Chemical Property:

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Technology Process of rac-1-methyl-3-phenyl-piperidin-3-ylamine

There total 4 articles about rac-1-methyl-3-phenyl-piperidin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1236302-32-1
rac-3-azido-3-phenyl-piperidine-1-carboxylic acid benzyl ester

: 1236302-33-2
rac-1-methyl-3-phenyl-piperidin-3-ylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 10 - 65 ℃;
DOI:10.1021/ml500005m

Reference yield:

: 61995-20-8
N-(benzyloxycarbonyl)-3-piperidone

: 1236302-33-2
rac-1-methyl-3-phenyl-piperidin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.75 h / 20 °C

2: sodium azide / water; trifluoroacetic acid / 3 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

With lithium aluminium tetrahydride; sodium azide; In tetrahydrofuran; water; trifluoroacetic acid;
DOI:10.1021/ml500005m

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1236302-33-2
rac-1-methyl-3-phenyl-piperidin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.75 h / 20 °C

2: sodium azide / water; trifluoroacetic acid / 3 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

With lithium aluminium tetrahydride; sodium azide; In tetrahydrofuran; water; trifluoroacetic acid;
DOI:10.1021/ml500005m