p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Base Information

Chemical Name:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate
CAS No.:412313-21-4
Molecular Formula:C₄₁H₄₇N₂O₆PS₃Si
Molecular Weight:819.091
Hs Code.:

p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Synonyms:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

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Chemical Property of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

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Technology Process of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

There total 10 articles about p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 412313-21-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / imidazole / CH₂Cl₂ / Ambient temperature

2: 1.) sodium isopropoxide / 1.) 5 min, isopropanol, 0 deg C, 2.) THF, 0 deg C, 45 min

3: 92 percent / benzene / 2 h / Heating

4: 1.) thionyl chloride, 2,6-lutidine, 2.) 2,6-lutidine / 1.) THF, -5 deg C, 20 min, 2.) 70 deg C, 4.5 h

With 1H-imidazole; 2,6-dimethylpyridine; thionyl chloride; sodium isopropylate; In dichloromethane; benzene;
DOI:10.1248/cpb.29.1854

Reference yield:

: 79759-95-8,125606-62-4,125606-68-0,137623-35-9,137623-36-0,138513-11-8
(3S*,4R*)-N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one

: 412313-21-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / ethyl acetate; acetic acid / 1 h / Ambient temperature

2: tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 1.5 h / 0 °C

3: 1.) sodium isopropoxide / 1.) 5 min, isopropanol, 0 deg C, 2.) THF, 0 deg C, 45 min

4: 92 percent / benzene / 2 h / Heating

5: 1.) thionyl chloride, 2,6-lutidine, 2.) 2,6-lutidine / 1.) THF, -5 deg C, 20 min, 2.) 70 deg C, 4.5 h

With 2,6-dimethylpyridine; thionyl chloride; tetrabutyl ammonium fluoride; sodium isopropylate; acetic acid; In tetrahydrofuran; acetic acid; ethyl acetate; benzene;
DOI:10.1248/cpb.29.1854

Reference yield:

: 76855-57-7
{[tert-butyl(dimethyl)silyl]oxy}ethane-1-thiol

: 412313-21-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium isopropoxide / 1.) 5 min, isopropanol, 0 deg C, 2.) THF, 0 deg C, 45 min

2: 92 percent / benzene / 2 h / Heating

3: 1.) thionyl chloride, 2,6-lutidine, 2.) 2,6-lutidine / 1.) THF, -5 deg C, 20 min, 2.) 70 deg C, 4.5 h

With 2,6-dimethylpyridine; thionyl chloride; sodium isopropylate; In benzene;
DOI:10.1248/cpb.29.1854