methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

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Chemical Name:methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate
CAS No.:1415797-92-0
Molecular Formula:C₁₆H₁₄FN₃O₃S
Molecular Weight:347.37
Hs Code.:

Synonyms:methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

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Chemical Property of methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

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Technology Process of methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

There total 8 articles about methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1415797-91-9
methyl 2-(dimethylamino)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

: 1765-93-1
4-fluoroboronic acid

: 1415797-92-0
methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

Guidance literature:: With pyridine; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 40 ℃; for 24h;

Reference yield:

: 214337-35-6
2-bromo-5-methoxy-thiazolo[5,4-b]pyridine

: 1415797-92-0
methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

Guidance literature:: Multi-step reaction with 6 steps

1: water; acetonitrile / 20 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

4: hydrogen bromide / 2 h / Reflux

5: thionyl chloride / Inert atmosphere; Reflux

6: pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) iodide / acetonitrile / 24 h / 40 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen bromide; zinc; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1415797-92-0
methyl 2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

Guidance literature:: Multi-step reaction with 8 steps

1: bromine; acetic acid / 2 h / 10 - 20 °C

2: copper(ll) bromide; isopentyl nitrite / acetonitrile / 2 h / Inert atmosphere; Reflux

3: water; acetonitrile / 20 °C

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

6: hydrogen bromide / 2 h / Reflux

7: thionyl chloride / Inert atmosphere; Reflux

8: pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) iodide / acetonitrile / 24 h / 40 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen bromide; bromine; acetic acid; copper(ll) bromide; zinc; isopentyl nitrite; In water; N,N-dimethyl-formamide; acetonitrile;