Technology Process of 3',5'-bis-[2-(2,4-dimethoxy-6-methoxycarbonyl-phenyl)-vinyl]-biphenyl-4-carboxylic acid
There total 7 articles about 3',5'-bis-[2-(2,4-dimethoxy-6-methoxycarbonyl-phenyl)-vinyl]-biphenyl-4-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
at 80 ℃;
for 12h;
DOI:10.1039/b506423f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: KOH / dimethylsulfoxide / 0.25 h / -78 °C
1.2: 87 percent / dimethylsulfoxide / 3 h / -78 - 20 °C
2.1: 71 percent / aq. K2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 12 h / 80 °C
With
potassium hydroxide; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; dimethyl sulfoxide;
2.1: Suzuki coupling;
DOI:10.1039/b506423f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 23 percent / NBS; benzoyl peroxide / CCl4 / 12 h / Heating
2.1: 68 percent / 18 h / 130 °C
3.1: 52 percent / t-BuOK / diethyl ether / 16 h / 0 - 20 °C
4.1: KOH / dimethylsulfoxide / 0.25 h / -78 °C
4.2: 87 percent / dimethylsulfoxide / 3 h / -78 - 20 °C
5.1: 71 percent / aq. K2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 12 h / 80 °C
With
potassium hydroxide; N-Bromosuccinimide; potassium tert-butylate; potassium carbonate; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrachloromethane; 1,2-dimethoxyethane; diethyl ether; dimethyl sulfoxide;
3.1: Horner-Emmons reaction / 5.1: Suzuki coupling;
DOI:10.1039/b506423f
