cyclohex-2-en-1-yl 4-fluorobenzoate

Base Information

• Chemical Name: cyclohex-2-en-1-yl 4-fluorobenzoate
• CAS No.: 1345403-77-1
• Molecular Formula: C₁₃H₁₃FO₂
• Molecular Weight: 220.243
• Mol file: 1345403-77-1.mol

Synonyms:cyclohex-2-en-1-yl 4-fluorobenzoate

Chemical Property of cyclohex-2-en-1-yl 4-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of cyclohex-2-en-1-yl 4-fluorobenzoate

There total 6 articles about cyclohex-2-en-1-yl 4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-Fluorobenzoic acid (456-22-4) + cyclohexene (110-83-8) → cyclohex-2-en-1-yl 4-fluorobenzoate (1345403-77-1)

Guidance literature:

With di-tert-butyl peroxide; C₁₁H₂₃N₂⁽¹⁺⁾*Br₄Fe^(1-); In ethyl acetate; at 110 ℃; for 24h;

DOI:10.1016/j.tetlet.2017.05.039

Reference yield: 87.0%

cyclohexane (110-82-7,25012-93-5) + 4-Fluorobenzoic acid (456-22-4) → cyclohex-2-en-1-yl 4-fluorobenzoate (1345403-77-1)

Guidance literature:

With (tetraphenylporphyrin)copper(II); di-tert-butyl peroxide; at 120 ℃; for 12h; Schlenk technique;

DOI:10.1016/j.tet.2021.132377

Reference yield: 80.0%

tert-butyl 4-fluorobenzoperoxoate (56263-57-1) + cyclohexene (110-83-8) → cyclohex-2-en-1-yl 4-fluorobenzoate (1345403-77-1)

Guidance literature:

With copper(I) bromide; at 40 ℃; for 36h;

DOI:10.1039/c5ra27500h

upstream raw materials:

tert-butyl 4-fluorobenzoperoxoate

cyclohexene

4-fluorobenzaldehyde

4-Fluorobenzoic acid

Refernces

• 1、 Mondal, Rakesh,Chakraborty, Gargi,van Vliet, Kaj M.,van Leest, Nicolaas P.,de Bruin, Bas,Paul, Nanda D.. "Copper-catalyzed oxidative dehydrogenative functionalization of alkanes to allylic esters". supporting information. . Retrieved 2019/11/11.
• 2、 Li, Chengliang,Deng, Hongmei,Jin, Tao,Li, Chunju,Jia, Xueshun,Li, Jian. "NHPI- and TBAI-Co-Catalyzed Synthesis of Allylic Esters from Toluene Derivatives and Alkenes". supporting information. p. 840 - 844. Retrieved 2018/01/27.