C₁₃H₁₆BrNO₃

Base Information

• Chemical Name: C₁₃H₁₆BrNO₃
• CAS No.: 1403595-70-9
• Molecular Formula: C₁₃H₁₆BrNO₃
• Molecular Weight: 314.179
• Mol file: 1403595-70-9.mol

Synonyms:C₁₃H₁₆BrNO₃

Chemical Property of C₁₃H₁₆BrNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₆BrNO₃

There total 5 articles about C₁₃H₁₆BrNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester (1403257-49-7) → C13H16BrNO3 (1403595-70-9)

Guidance literature:

2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester; With water; sodium hydroxide; In methanol; at 60 ℃; for 1h;

With hydrogenchloride; citric acid; In water; pH=4 - 6;

Reference yield:

2-methyl-3-amino-5-bromobenzoic acid methyl ester (1000342-11-9) → C13H16BrNO3 (1403595-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

1.2: 64 h

2.1: sodium hydroxide; water / methanol / 1 h / 60 °C

2.2: pH 4 - 6

With water; acetic acid; sodium hydroxide; In methanol; 1,2-dichloro-ethane;

Reference yield:

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester (220514-28-3) → C13H16BrNO3 (1403595-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

2.2: 64 h

3.1: sodium hydroxide; water / methanol / 1 h / 60 °C

3.2: pH 4 - 6

With water; iron; ammonium chloride; acetic acid; sodium hydroxide; In methanol; ethanol; water; 1,2-dichloro-ethane;

upstream raw materials:

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

2-methyl-3-amino-5-bromobenzoic acid methyl ester

2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

Tetrahydro-4H-pyran-4-one

Downstream raw materials:

5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide