5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Base Information

Chemical Name:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide
CAS No.:1403590-75-9
Molecular Formula:C₂₁H₂₆BrN₃O₃
Molecular Weight:448.36
Hs Code.:

Synonyms:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

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Chemical Property of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

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Technology Process of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

There total 8 articles about 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403595-70-9
C₁₃H₁₆BrNO₃

: 1403590-75-9
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₃H₁₆BrNO₃; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethylpyridin-2-ol

: 1403595-70-9
C₁₃H₁₆BrNO₃

: 1403590-75-9
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01501

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403590-75-9
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

1.2: 64 h

2.1: sodium hydroxide; water / methanol / 1 h / 60 °C

2.2: pH 4 - 6

3.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; acetic acid; sodium hydroxide; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;