benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Base Information

Chemical Name:benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate
CAS No.:1383973-81-6
Molecular Formula:C₂₂H₂₆N₄O₃
Molecular Weight:394.473
Hs Code.:

Synonyms:benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Suppliers and Price of benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

There total 10 articles about benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4994-86-9
4-chloro-2-methylpyrimidine

: 1396379-54-6
benzyl 5-carbamoylbicyclo[3.2.1]octan-1-ylcarbamate

: 1383973-81-6
benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 62638-06-6
dimethyl cyclohexane-1,3-dicarboxylate

: 1383973-81-6
benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 25 °C

2.1: diisopropylamine; n-butyllithium / hexane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrahydrofuran / -78 - 25 °C / Inert atmosphere

3.1: water; barium hydroxide octahydrate / ethanol / Inert atmosphere; Reflux

3.2: 18 - 25 °C / pH 1 - 2

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 4 h / 18 - 25 °C / Inert atmosphere; Reflux

4.2: Reflux

5.1: sodium hydroxide; water / methanol / 2 h / Inert atmosphere; Reflux

5.2: 18 - 25 °C / pH 1 - 2

6.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 18 - 25 °C / Inert atmosphere

7.1: ammonia / tetrahydrofuran / 0.5 h / 18 - 25 °C / Inert atmosphere

8.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; barium hydroxide octahydrate; diphenyl phosphoryl azide; ammonia; water; caesium carbonate; triethylamine; diisopropylamine; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; ethanol; hexane; dichloromethane; toluene; 4.1: Curtius Rearrangement;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1383973-81-6
benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 4 h / 18 - 25 °C / Inert atmosphere; Reflux

1.2: Reflux

2.1: sodium hydroxide; water / methanol / 2 h / Inert atmosphere; Reflux

2.2: 18 - 25 °C / pH 1 - 2

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 18 - 25 °C / Inert atmosphere

4.1: ammonia / tetrahydrofuran / 0.5 h / 18 - 25 °C / Inert atmosphere

5.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With oxalyl dichloride; diphenyl phosphoryl azide; ammonia; water; caesium carbonate; triethylamine; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; toluene; 1.1: Curtius Rearrangement;