4994-86-9

Basic information

• Product Name: 4-CHLORO-2-METHYLPYRIMIDINE
• Synonyms: 4-CHLORO-2-METHYLPYRIMIDINE;CHEMBRDG-BB 4015462;Pyrimidine, 4-chloro-2-methyl- (7CI,8CI,9CI);4-Chloro-2-methylpyrimidine95%;2-methyl-4-chloro-[3,4-d]-pyrimidine;4-chloro-2-methylpyrimidine(SALTDATA: FREE);2-Methyl-4-chloropyriMidine;Pyrimidine, 4-chloro-2-methyl-
• CAS NO: 4994-86-9
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 4994-86-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 55.0 to 59.0 °C
• Boiling Point: 168°C(lit.)
• Flash Point: 70.061 °C
• Appearance: /
• Density: 1.235 g/cm³
• Vapor Pressure: 2.055mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 0.47±0.20(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLPYRIMIDINE(4994-86-9)
• EPA Substance Registry System: 4-CHLORO-2-METHYLPYRIMIDINE(4994-86-9)

Safety Data

• Hazardous Substances Data: 4994-86-9(Hazardous Substances Data)

Usage

Uses

4-Chloro-2-methylpyrimidine is a reagent in the preparation of (pyridylmethyl)-/(pyrimidin-4-ylmethyl)-dihydroquinolines as antagonists against CXCR4.

InChI:InChI=1/C5H5ClN2/c1-4-7-3-2-5(6)8-4/h2-3H,1H3

Upstream product

• 19875-04-8 4-hydroxy-2-methyl-pyrimidine 
• 19875-04-8 2-methylpyrimidin-4-one 
• 19875-04-8 2-methyl-3H-pyrimidin-4-one 
• 10025-87-3 trichlorophosphate 
• 930-61-0 2,4-dimethyl-2-imidazoline 
• 67-66-3 chloroform 
• 693-98-1 2-methylimidazole 

Downstream Products

• 74-69-1 2-methyl-pyrimidin-4-ylamine 
• 1272758-33-4 4-chloro-2-methylpyrimidine hydrochloride 
• 7314-65-0 4-methoxy-2-methyl-pyrimidine 
• 1440426-39-0 C₁₇H₁₉N₇ 
• 1448541-19-2 N-(2-methylpyrimidin-4-yl)-2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]propanamide 

Relevant articles and documents

Synthetic method of 4-chlorine-2-methylpyrimidine

The invention discloses a synthetic method of 4-chlorine-2-methylpyrimidine. Step1, 2-methyl-4-hydroxypyrimidine, phosphorus oxychloride and organic alkali are mixed by weight ratio of 1 to 5-10 to 0.3-0.7, chlorination reaction is conducted at 25-100 DEG C for 2-5 hours; and step 2, after reaction is completed, the mixture is cooled, then vacuum concentration is conducted to remove the phosphorusoxychloride, after water is added to quench, extraction is conducted by using an organic solvent, and a product is obtained after drying and concentration. According to the synthetic method of the 4-chlorine-2-methylpyrimidine, the synthetic route is short, synthesis is convenient, the yield is high, the toxicity of the raw materials is low, environmental pollution is reduced, and environment-friendly production is achieved.

PIPERAZINE SUBSTITUTED PYRIMIDINE DERIVATIVES AND PHYSIOLOGICALLY TOLERATED SALTS THEREOF

Pyrimidine derivatives of the formula I I in which R1, R2, R3, R4 and R5 have the indicated meanings, the salts thereof, and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable as a tool in a pharmacological screening model for aldose reductase inhibitors

Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

The vapor-phase reactions of imidazolines and anils with chloroform at 550 deg C are compared with their liquid-phase reactions in the presence of hexachloroacetone and base or upon thermolysis with trichloroacetate ion.In the vapour-phase reactions imidazolines, unlike imidazoles, gave non-chlorinated pyrimidines, and 1-methyl-imidazole gave 2-cyanopyrrole and the four 3-chlorocyanopyridines.