methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate

Base Information

• Chemical Name: methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate
• CAS No.: 934842-20-3
• Molecular Formula: C₁₉H₁₃F₉INO₂
• Molecular Weight: 585.208
• Mol file: 934842-20-3.mol

Synonyms:methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate

Chemical Property of methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate

There total 1 articles about methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl [2-amino-5-(trifluoromethyl)benzyl][3,5-bis(trifluoromethyl)benzyl]carbamate (868166-10-3) → methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate (934842-20-3)

Guidance literature:

With iodine; isopentyl nitrite; In chloroform; Reflux;

DOI:10.1016/j.bmcl.2010.10.019

Reference yield:

(2-chloro-5-nitrophenyl)boronic acid (867333-29-7) + methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate (934842-20-3) → C25H16ClF9N2O4 (934842-30-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 2h; Heating / reflux;

Reference yield:

methyl [3,5-bis(trifluoromethyl)benzyl][2-iodo-5-(trifluoromethyl)benzyl]carbamate (934842-20-3) + 2-Cyanophenylboronic acid (138642-62-3) → methyl [3,5-bis(trifluoromethyl)benzyl]{[2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}carbamate

Guidance literature:

With potassium fluoride; palladium diacetate; CyJohnPhos; In 1,4-dioxane; at 80 ℃;

upstream raw materials:

methyl [2-amino-5-(trifluoromethyl)benzyl][3,5-bis(trifluoromethyl)benzyl]carbamate

Downstream raw materials:

methyl [3,5-bis(trifluoromethyl)benzyl][2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]carbamate

C₂₅H₁₆ClF₉N₂O₄