3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid

Base Information

Chemical Name:3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid
CAS No.:121494-14-2
Molecular Formula:C₁₄H₁₉NO₄
Molecular Weight:265.309
Hs Code.:
DSSTox Substance ID:DTXSID501224347

Synonyms:3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid;121494-14-2;SCHEMBL5090319;DTXSID501224347;CS-0457118;EN300-3306718;3-{[(tert-butoxy)carbonyl](phenyl)amino}propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:265.13140809
Heavy Atom Count:19
Complexity:316

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(CCC(=O)O)C1=CC=CC=C1

Technology Process of 3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid

There total 3 articles about 3-((Tert-butoxycarbonyl)(phenyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 5652-38-0
N-phenyl-β-alanine

: 121494-14-2
3-((tert-butoxycarbonyl)(phenyl)amino)propanoic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 21h;
DOI:10.1021/acs.joc.9b00432

Reference yield: 64.4%

: 24424-99-5
di-tert-butyl dicarbonate

: 15727-49-8
N-Phenylalanin

: 121494-14-2
3-((tert-butoxycarbonyl)(phenyl)amino)propanoic acid

Guidance literature:: With hydrogenchloride; sodium hydroxide; In chloroform;

Reference yield:

: 21911-84-2
methyl 3-(phenylamino)propanoate

: 121494-14-2
3-((tert-butoxycarbonyl)(phenyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water / 3 h / 20 °C

1.2: pH 3

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C

With sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; methanol; water;
DOI:10.1021/ol201526g