4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

Base Information

Chemical Name:4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide
CAS No.:1477815-93-2
Molecular Formula:C₁₇H₂₂BrF₃N₄O₂
Molecular Weight:451.286
Hs Code.:

Synonyms:4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

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Chemical Property of 4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

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Technology Process of 4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

There total 4 articles about 4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1477815-41-0
4-[4-(4-bromo-3-trifluoromethoxyphenylcarbamoyl)piperazin-1-yl]piperidine-1-carboxylic acid tert-butyl ester

: 1477815-93-2
4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1477815-93-2
4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 20 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: dichloromethane / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 177276-40-3
4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazine-1-carboxylic acid benzyl ester

: 1477815-93-2
4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 20 °C / 2585.81 Torr / Inert atmosphere

2.1: dichloromethane / 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; hydrogen; In 1,4-dioxane; dichloromethane; isopropyl alcohol;