Technology Process of 5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester>
There total 7 articles about 5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester> which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
acetonitrile;
for 72h;
Ambient temperature;
DOI:10.1021/jm00171a038
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 11.1 g / H2 / 5percent Pd/C / ethanol; H2O / 2016.9 Torr / Ambient temperature
2: NaOH / H2O; tetrahydrofuran / Ambient temperature
3: 59 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH2Cl2 / 20 h / Ambient temperature
4: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / 72 h / Ambient temperature
With
dmap; sodium hydroxide; hydrogen; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00171a038
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaOH / H2O; tetrahydrofuran / Ambient temperature
2: 59 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH2Cl2 / 20 h / Ambient temperature
3: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / 72 h / Ambient temperature
With
dmap; sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00171a038
