130327-97-8

Upstream product

• 10258-93-2 N-(2-cyclohexyl-ethyl)-ethylenediamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 130327-96-7 N-(1,1-dimethylethoxycarbonyl)-N-<2-ethyl>glycine 
• 130327-95-6 N-(2-(2-Cyclohexylethylamino)ethyl)glycine 

Downstream Products

• 130328-01-7 5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester> 
• 130328-03-9 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester> dihydrochloride 
• 130328-02-8 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester> 

Relevant academic research and scientific papers

Cyclization-Activated Prodrugs. Basic Esters of 5-Bromo-2'-deoxyuridine

Some 3'- and 5'-glycyl> esters of 5-bromo-2'-deoxyuridine were prepared and evaluated in vitro as progenitors of the parent alcohol.The sters proved to be relatively stable at low pH but released 5-bromo-2'-deoxyuridine cleanly at rates which were pH and structure dependent.These basic esters are examples of cyclization-activated prodrugs in which generation of active drug is not linked to enzymatic cleavage but rather results from an intramolecular cyclization-elimination reaction.

Halogenated pyrimidine nucleosides and their derivatives

Halogenated pyrimidine nucleoside derivatives with improved aqueous solubility and methods of enhancing the concentration of drugs in malignant tumors and promoting uniform distribution of the drug throughout the tumor. These basic and hydrophilic ester p