(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

Base Information

Chemical Name:(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide
CAS No.:640727-92-0
Molecular Formula:C₁₉H₂₅N₃O₄S
Molecular Weight:391.491
Hs Code.:

Synonyms:(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

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Chemical Property of (1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

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Technology Process of (1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

There total 3 articles about (1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 640727-92-0
(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2.1: 47 percent / aq. Oxone(R) / methanol; CH₂Cl₂ / 1 h / 0 - 20 °C

3.1: 88 percent / methanol / 70 °C

4.1: trimethylaluminum / hexane; CH₂Cl₂ / 1.42 h / 0 - 20 °C

4.2: 67 percent / hexane; CH₂Cl₂ / 2 h / 20 °C

With oxone; trimethylaluminum; sodium methylate; In methanol; hexane; dichloromethane; toluene;
DOI:10.1021/jm030276s

Reference yield:

: 346684-15-9
methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

: 640727-92-0
(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 47 percent / aq. Oxone(R) / methanol; CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: 88 percent / methanol / 70 °C

3.1: trimethylaluminum / hexane; CH₂Cl₂ / 1.42 h / 0 - 20 °C

3.2: 67 percent / hexane; CH₂Cl₂ / 2 h / 20 °C

With oxone; trimethylaluminum; In methanol; hexane; dichloromethane;
DOI:10.1021/jm030276s

Reference yield:

: 640727-90-8
methyl (2Z)-2-hydroxy-4-(4-(methylsulfonyl)phenyl)-4-oxo-but-2-enoate

: 640727-92-0
(1-cyclohexyl-5-[(4-methylsulfonyl)phenyl]pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / methanol / 70 °C

2.1: trimethylaluminum / hexane; CH₂Cl₂ / 1.42 h / 0 - 20 °C

2.2: 67 percent / hexane; CH₂Cl₂ / 2 h / 20 °C

With trimethylaluminum; In methanol; hexane; dichloromethane;
DOI:10.1021/jm030276s