methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

Base Information

Chemical Name:methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate
CAS No.:581065-59-0
Molecular Formula:C₂₃H₂₃F₃O₇S₂
Molecular Weight:532.559
Hs Code.:

Synonyms:methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

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Chemical Property of methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

There total 8 articles about methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 581065-58-9
methyl 4-hydroxy-6-iso-propoxy-2-(4-iso-propoxyphenyl)benzo[b]thiophene-3-carboxylate

: 581065-59-0
methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo034325k

Reference yield:

: 96501-80-3
2,4-diisopropoxybenzene-1-carboaldehyde

: 581065-59-0
methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 69 percent / LDA / tetrahydrofuran; hexane / 8 h / -78 - 20 °C

2.1: MeSO₃H / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3.1: 4.16 g / aq. HCl / ethanol / 12 h / Heating

4.1: piperidine / acetic acid / 12 h / Heating

4.2: 77 percent / aq. KOH / 1 h / 20 °C

5.1: 92 percent / DDQ / benzene / 24 h / Heating

6.1: 96 percent / BCl₃ / CH₂Cl₂; heptane / 2 h / -78 - 0 °C

7.1: 83 percent / NEt₃ / CH₂Cl₂ / 1 h / 0 - 20 °C

With piperidine; hydrogenchloride; methanesulfonic acid; boron trichloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo034325k

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 581065-59-0
methyl 6-iso-propoxy-2-(4-iso-propoxyphenyl)-4-{[(trifluoromethyl)sulfonyl]oxy}benzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 93 percent / K₂CO₃ / acetonitrile / 72 h / Heating

2.1: 69 percent / LDA / tetrahydrofuran; hexane / 8 h / -78 - 20 °C

3.1: MeSO₃H / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4.1: 4.16 g / aq. HCl / ethanol / 12 h / Heating

5.1: piperidine / acetic acid / 12 h / Heating

5.2: 77 percent / aq. KOH / 1 h / 20 °C

6.1: 92 percent / DDQ / benzene / 24 h / Heating

7.1: 96 percent / BCl₃ / CH₂Cl₂; heptane / 2 h / -78 - 0 °C

8.1: 83 percent / NEt₃ / CH₂Cl₂ / 1 h / 0 - 20 °C

With piperidine; hydrogenchloride; methanesulfonic acid; boron trichloride; potassium carbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; acetic acid; acetonitrile; benzene;
DOI:10.1021/jo034325k