96501-80-3

Usage

General Description

2,4-bis(propan-2-yloxy)benzaldehyde, also known as "dipropylene glycol benzaldehyde," is a chemical compound with the molecular formula C17H20O3. It is an organic compound consisting of a benzene ring with two propan-2-yloxy groups and an aldehyde functional group attached to it. This chemical is commonly used as a fragrance ingredient in cosmetic and personal care products, as well as in the manufacturing of various industrial products. It is known for its sweet, almond-like aroma and is often used to add a pleasant scent to perfumes, lotions, and soaps. Additionally, it may be utilized as a flavoring agent in food products and as a scent additive in household cleaning products.

Upstream product

• 75-30-9 2-iodo-propane 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 75-26-3 isopropyl bromide 
• 52085-11-7 2-hydroxy-4-iso-propyloxybenzaldehyde 
• 79128-08-8 1,3-diisopropoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 83162-82-7 2',4',5-trihydroxy-5',6,7-trimethoxyflavone 
• 96501-88-1 2',4',5,7-tetraisopropyloxy-5',6-dimethoxyflavone 
• 96501-87-0 2'-hydroxy-2,4,4',6'-tetraisopropyloxy-5,5'-dimethoxychalcone 
• 96410-40-1 2',4'-diisopropyloxy-5,5',6,7,8-pentamethoxyflavone 
• 96410-39-8 2'-hydroxy-2,4-diisopropyloxy-3',4',5,5',6'-pentamethoxychalcone 
• 77053-48-6 2',4',5-trihydroxy-5',6,7,8-tetramethoxyflavone 
• 81979-84-2 2′,4′,5,7-tetrahydroxy-5′,6-dimethoxyflavone 
• 96410-43-4 2,4-diisopropyloxy-5-methoxybenzaldehyde 
• 111786-42-6 2'-hydroxy-2,4-diisopropyloxy-4',5,5',6'-tetramethoxychalcone 

Relevant academic research and scientific papers

CHRYSOPHAENTIN ANALOGS AND USE THEREOF

Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activitivies that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds.

HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds or compositions disclosed herein for treating and/or preventing proliferative diseases, cancers, carcinoma lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, leukemia, sarcoma and/or cardiovascular diseases in a subject in need thereof. In certain embodiments, the sarcoma is Ewing's sarcoma. Provided are methods of inhibiting a histone demethylase in a subject and/or in a cell, tissue, or biological sample. In certain embodiments, the histone demethylase is a KDM. In certain embodiments, the KDM is KDM5. In certain embodiments, the biological sample is a cell. In certain embodiments, the biological sample is a tissue.

Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis

Chrysophaentin A is an antimicrobial natural product isolated from the marine alga C. taylori in milligram quantity. Structurally, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubstituted chloroalkenes at its periphery. A concise synthesis of iso-and 9-dechlorochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an oxygen to carbon ring contraction is described. Fluorescent microscopy studies revealed 9-dechlorochrysophaentins leads to inhibition of bacterial cell wall biosynthesis by disassembly of key divisome proteins, the cornerstone to bacterial cell wall biosynthesis and division.

Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction

A novel class of small-molecule inhibitors of MDM2-p53 interaction with a (E)-3-benzylideneindolin-2-one scaffold was identified using an integrated virtual screening strategy that combined both pharmacophore- and structure-based approaches. The hit optimisation identified several compounds with more potent activity than the hit compound and the positive drug nutlin-3a, especially compound 1b, which exhibited both the highest binding affinity to MDM2 (K i = 0.093 μM) and the most potent antiproliferative activity against HCT116 (wild type p53) cells (GI50 = 13.42 μM). Additionally, 1b dose-dependently inhibited tumour growth in BALB/c mice bearing CT26 colon carcinoma, with no visible sign of toxicity. In summary, compound 1b represents a novel and promising lead structure for the development of anticancer drugs as MDM2-p53 interaction disruptors.

COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES

Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.

A novel synthesis of parent resorc[4]arene and its partial alkyl ethers

Treatment of 2,4-diisopropoxybenzyl alcohol with chlorotrimethylsilane in acetonitrile at room temperature for 1h afforded a novel crystalline resorc[4]arene octaisopropyl ether in 96% yield. Protecting groups were cleaved by boron trichloride in dichloromethane within 30min and the parent resorc[4]arene was isolated by flash chromatography in 76% yield. The outcome of the deprotection step was dependent on the conditions used as it is exemplified by a preparation of resorc[4]arene heptaisopropyl ether.

Ruthenium olefin metathesis catalysts with modified styrene ethers: Influence of steric and electronic effects

A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesised, and the effects of ligands on the rate of metathesis investigated. Increased steric hinderance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron density at both the chelating oxygen atom and the Ru=C bond accelerated reaction rates appreciably. Catalysts containing a tricyclohexylphosphane ligand, followed the same trend with regard to benzylidene electrophilicity, while higher electron density at oxygen enhanced reaction rates.

Synthesis of constrained raloxifene analogues by complementary use of Friedel-Crafts and directed remote metalation reactions

New constrained heterocyclic analogues, 2a,b and 3, of Raloxifene (1) have been prepared by complementary Directed remote Metalation (DreM)/Friedel-Crafts cyclization approaches. Utilization of a benzylidene-thiolactone rearrangement was successfully impl

Syntheses of isochromane analogues of the michellamines and korupensamines

Syntheses of the oxygen analogues 6, 7 and 8 of the michellamines 1 and korupensamines 2 are described. Racemic 5-iodo-6,8-dimethoxy-trans-1,3-dimethylisochromane 10 was synthesised in eleven steps from 2,4-dimethoxybenzaldehyde in an overall yield of 51%

Synthesis of Alkoxybenzenes and Alkoxyvinylbenzenes and Their Chemosterilizing and Toxic Activity on Planococcus citri (Hom., Pseudococcidea)

Dialkoxy-, trialkoxy-, dialkoxyvinyl-, and trialkoxyvinylbenzenes were investigated for chemosterilant and toxic activity on Planococcus citri.The alkoxyvinylbenzenes were toxic; they reduced the egg production of the test insect.Dialkoxyvinylbenzenes dec