3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

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Chemical Name:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide
CAS No.:1369872-12-7
Molecular Formula:C₂₃H₂₆F₃N₇O₂
Molecular Weight:489.5
Hs Code.:

Synonyms:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

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Chemical Property of 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

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Technology Process of 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

There total 7 articles about 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.2%

: 536748-06-8
4-amino-3-fluoro-N,N-dimethylbenzamide

: 1369872-05-8
5-(1-(6-chloro-5-fluoropyrimidin-4-yl)piperidin-4-yl)-3-(2-fluoropropan-2-yl)-1,2,4-oxadiazole

: 1369872-12-7
3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

Guidance literature:: With caesium carbonate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; at 95 ℃; for 1h; Inert atmosphere;

Reference yield:

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1369872-12-7
3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 0 - 20 °C

2: caesium carbonate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 1 h / 95 °C / Inert atmosphere

With caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; acetonitrile;

Reference yield:

: 536748-06-8
4-amino-3-fluoro-N,N-dimethylbenzamide

: 1369872-12-7
3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2 h / 102 °C / Inert atmosphere

2.1: triethylamine; lithium bromide / acetonitrile; water / 16 h / 50 - 75 °C

2.2: pH 1 / Cooling with ice

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h

3.2: 16 h

4.1: ISOPROPYLAMIDE / 4 h / 110 °C / Inert atmosphere

With caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; lithium bromide; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; ISOPROPYLAMIDE; water; acetonitrile;