ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

Base Information

Chemical Name:ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate
CAS No.:152623-07-9
Molecular Formula:C₂₇H₃₄N₄O₅S₂
Molecular Weight:558.723
Hs Code.:

Synonyms:ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

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Chemical Property of ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

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Technology Process of ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

There total 11 articles about ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56503-39-0
ethyl (2E)-cyano(hydroxyimino)ethanoate

: 152623-07-9
ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / H₂, water / 5percent Pd/C / tetrahydrofuran / 10 h / Ambient temperature

2: triethylamine / ethanol / 50 h / 0 °C

3: 67 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: conc. HCl / ethanol / 2 h / Heating

6: K₂CO₃ / acetone / 2 h / Heating

With hydrogenchloride; dmap; phosphorus pentachloride; water; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00013a013

Reference yield:

: 90566-07-7
ethyl cyano<(1-oxobutyl)amino>acetate

: 152623-07-9
ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 50 h / 0 °C

2: 67 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: conc. HCl / ethanol / 2 h / Heating

5: K₂CO₃ / acetone / 2 h / Heating

With hydrogenchloride; dmap; phosphorus pentachloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00013a013

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 152623-07-9
ethyl 2-n-propyl-1-[(2'-n-propylaminocarbonylaminosulfonyl-biphenyl-4-yl)methyl]-4-methylthio-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

3: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: conc. HCl / ethanol / 2 h / Heating

6: K₂CO₃ / acetone / 2 h / Heating

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00013a013