1H-Imidazole-5-carboxylic acid, 1-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-4-(methylthio)-2-propyl-, ethyl ester

Base Information

Chemical Name:1H-Imidazole-5-carboxylic acid, 1-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-4-(methylthio)-2-propyl-, ethyl ester
CAS No.:152623-33-1
Molecular Formula:C23H27N3O4S2
Molecular Weight:473.617
Hs Code.:
Mol file:152623-33-1.mol

Synonyms:

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Chemical Property of 1H-Imidazole-5-carboxylic acid, 1-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-4-(methylthio)-2-propyl-, ethyl ester

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Technology Process of 1H-Imidazole-5-carboxylic acid, 1-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-4-(methylthio)-2-propyl-, ethyl ester

There total 10 articles about 1H-Imidazole-5-carboxylic acid, 1-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-4-(methylthio)-2-propyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56503-39-0
ethyl (2E)-cyano(hydroxyimino)ethanoate

: 152623-33-1
5-Methylsulfanyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / H₂, water / 5percent Pd/C / tetrahydrofuran / 10 h / Ambient temperature

2: triethylamine / ethanol / 50 h / 0 °C

3: 67 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; dmap; phosphorus pentachloride; water; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013

Reference yield:

: 3-(2'-{[1-Dimethylamino-meth-(E)-ylidene]-sulfamoyl}-biphenyl-4-ylmethyl)-5-methylsulfanyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

: 152623-33-1
5-Methylsulfanyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; In ethanol; for 2h; Heating;
DOI:10.1021/jm00013a013

Reference yield:

: 90566-07-7
ethyl cyano<(1-oxobutyl)amino>acetate

: 152623-33-1
5-Methylsulfanyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / 50 h / 0 °C

2: 67 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; dmap; phosphorus pentachloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013