3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

Base Information

Chemical Name:3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine
CAS No.:126916-77-6
Molecular Formula:C₁₉H₁₅ClF₂N₄O₂
Molecular Weight:404.804
Hs Code.:

Synonyms:3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

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Chemical Property of 3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

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Technology Process of 3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

There total 4 articles about 3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 126916-75-4
5-(2,4-Difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

: 122-01-0
4-chloro-benzoyl chloride

: 126916-77-6
3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

Guidance literature:: With triethylamine; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.38.2476

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 126916-77-6
3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaN₃, NH₄Cl / dimethylformamide / 0.33 h / 60 °C

2: 97 percent / H₂ / 10percent Pd/C / ethanol / 1 h / Ambient temperature

3: 100 percent / toluene / 2 h / 80 °C

4: 50 percent / NEt₃ / 0.5 h / 0 °C

With sodium azide; hydrogen; ammonium chloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.38.2476

Reference yield:

: 132507-80-3
1?azido?2?(2,4?difluorophenyl)?3?(1H?1,2,4?triazol?1?yl)propan?2?ol

: 126916-77-6
3-(4-Chlorobenzoyl)-5-(2,4-difluorophenyl)-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / 10percent Pd/C / ethanol / 1 h / Ambient temperature

2: 100 percent / toluene / 2 h / 80 °C

3: 50 percent / NEt₃ / 0.5 h / 0 °C

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1248/cpb.38.2476