Technology Process of 2-chloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
There total 9 articles about 2-chloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-3,4-bis[(4-methoxybenzyl)oxy]benzoic acid;
With
methanesulfonyl chloride; triethylamine;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 0.5h;
Inert atmosphere;
1-(2-aminoethyl)pyrrolidine;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.ejmech.2018.06.014
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / 3.5 h / 0 - 20 °C
1.2: Cooling with ice
2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 70 °C
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.33 h / 70 °C
4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl acetamide / 1 h / -15 °C
4.2: 1 h / -15 °C
With
water; boron tribromide; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aminosulfonic acid; sodium chlorite / 1,4-dioxane; water / 0.5 h / 0 °C / Inert atmosphere
2.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere
4.1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere
5.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere
5.2: 1 h / 0 °C / Inert atmosphere
With
sodium chlorite; aminosulfonic acid; boron tribromide; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014
