Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

Base Information

Chemical Name:Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester
CAS No.:443361-68-0
Molecular Formula:C₁₂H₁₁F₃O₄S
Molecular Weight:308.278
Hs Code.:

Synonyms:Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

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Chemical Property of Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

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Technology Process of Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

There total 2 articles about Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-20-6,24991-31-9
vinyl n-butyrate

: 88462-65-1
(+/-)-4-[(3-trifluoromethyl)phenoxy]-1-butyne-3-ol

: 124-63-0
methanesulfonyl chloride

: 443361-68-0
Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

: Methanesulfonic acid (R)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

: 301834-95-7
(R)-4-[3-(trifluoromethyl)phenoxy]-1-butyne-3-yl butyrate

Guidance literature:: vinyl n-butyrate; (+/-)-4-[(3-trifluoromethyl)phenoxy]-1-butyne-3-ol; With CHIRAZYME L-9; In n-heptane; at 22 ℃; for 45h; Enzymatic reaction;

methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 2 ℃; for 2.5h; Further stages. Title compound not separated from byproducts.;
DOI:10.1002/1615-4169(200201)344:1<50::AID-ADSC50>3.0.CO;2-5

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 301834-95-7
(R)-4-[3-(trifluoromethyl)phenoxy]-1-butyne-3-yl butyrate

: 443361-68-0
Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/op010097p

Reference yield:

: 443361-68-0
Methanesulfonic acid (S)-1-(3-trifluoromethyl-phenoxymethyl)-prop-2-ynyl ester

: (R)-4-(3-trifluoromethylphenoxy)-3-(tert-butyldimethylsilyloxy)-1-iodo-1E-butene

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / 1 h / 0 - 5 °C

1.2: 2 h / 110 - 120 °C

1.3: SO₃; pyridine / dimethylformamide

2.1: aq. KH₂PO₄; aq. NaOH; chirazyme L-2 / heptane; aq. KOH / 3 h / 28 - 32 °C / pH 6.9 - 7.1 / Enzymatic reaction

3.1: imidazole / dimethylformamide / 15 h / 20 °C

4.1: t-BuMgCl / Cp₂ZrCl₂ / toluene; diethyl ether / 5 h / 50 - 60 °C

4.2: I₂ / toluene; tetrahydrofuran / 1 h / -40 - 20 °C

With 1H-imidazole; sodium hydroxide; potassium dihydrogenphosphate; Chirazyme L-2; tert-butylmagnesium chloride; triethylamine; zirconocene dichloride; In potassium hydroxide; diethyl ether; n-heptane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1615-4169(200201)344:1<50::AID-ADSC50>3.0.CO;2-5