(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

Base Information

Chemical Name:(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester
CAS No.:142841-21-2
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

Synonyms:(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

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Chemical Property of (5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

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Technology Process of (5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

There total 5 articles about (5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143148-19-0
1-phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-(carboxymethyl)-2,3,6,7-tetrahydro-1H-azepine

: 142841-21-2
(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

Guidance literature:: With ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -20 ℃; Yield given;
DOI:10.1021/jm00099a027

Reference yield:

: 143148-18-9
1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[(2-hydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

: 142841-21-2
(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 0 °C / Jones oxidation

2: 1.) EtO₂CCl, Et₃N, 2.) NH₄OH / tetrahydrofuran / -20 °C

With ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; acetone;
DOI:10.1021/jm00099a027

Reference yield:

: 142841-20-1
1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

: 142841-21-2
(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: nBu₄NF / tetrahydrofuran / Ambient temperature

2: acetone / 0 °C / Jones oxidation

3: 1.) EtO₂CCl, Et₃N, 2.) NH₄OH / tetrahydrofuran / -20 °C

With ammonium hydroxide; tetrabutyl ammonium fluoride; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; acetone;
DOI:10.1021/jm00099a027