1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

Base Information

• Chemical Name: 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine
• CAS No.: 142841-20-1
• Molecular Formula: C₃₉H₄₃NO₄Si
• Molecular Weight: 617.86

Synonyms:1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

Chemical Property of 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

Chemical Property:

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Technology Process of 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

There total 2 articles about 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ammonium chloride + 1-Phenyl-2-oxo-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine (142841-19-8) + lithium hexamethyldisilazane (4039-32-1) + Benzyl bromoacetate (5437-45-6) → 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine (142841-20-1)

Guidance literature:

In tetrahydrofuran;

Reference yield:

2-(4-Methoxyphenyl)ethanol (702-23-8) + aniline (62-53-3) + tert-butylchlorodiphenylsilane (58479-61-1) + Benzyl bromoacetate (5437-45-6) → 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine (142841-20-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00099a027

Reference yield:

1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[2-(t-butyldiphenylsilylhydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine (142841-20-1) → 1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[(2-hydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine (143148-18-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00099a027

upstream raw materials:

2-(4-Methoxyphenyl)ethanol

aniline

tert-butylchlorodiphenylsilane

Benzyl bromoacetate

Downstream raw materials:

1-Phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-[(2-hydroxy)ethyl]-2,3,6,7-tetrahydro-1H-azepine

(5-Aminomethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

(5-Carbamoylmethyl-2-oxo-1-phenyl-2,3,6,7-tetrahydro-1H-azepin-3-yl)-acetic acid benzyl ester

1-phenyl-2-oxo-3-(carbobenzyloxy)methyl-5-(carboxymethyl)-2,3,6,7-tetrahydro-1H-azepine

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