(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

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Chemical Name:(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol
CAS No.:568571-89-1
Molecular Formula:C₄₄H₅₂O₉
Molecular Weight:724.891
Hs Code.:

(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

Synonyms:(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

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Chemical Property of (2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

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Technology Process of (2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

There total 19 articles about (2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 568571-88-0
(2R,4aR,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

: 568571-89-1
(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

: (2R,4aR,6S,7S,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

Guidance literature:: (2R,4aR,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(03)00949-3

Reference yield:

: 568571-87-9
(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

: 568571-89-1
(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

1.2: 9.46 g / Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 14 h / 50 °C

2.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

2.2: 2.98 g / aq. H₂O₂; NaOH / tetrahydrofuran / 2.5 h / 20 °C

With 9-borabicyclo[3.3.1]nonane dimer; dimethylsulfide borane complex; In tetrahydrofuran; 1.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r

Reference yield:

: 568571-86-8
[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-yl]-methanol

: 568571-89-1
(2R,4aR,6S,7R,9aS)-6-[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-ylmethyl]-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / I₂; imidazole; PPh₃ / benzene / 0.58 h / 20 °C

2.1: 95 percent / potassium t-butoxide / tetrahydrofuran / 1.5 h / 0 °C

3.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

3.2: 9.46 g / Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 14 h / 50 °C

4.1: BH₃*SMe₂ / tetrahydrofuran / 4 h / 0 °C

4.2: 2.98 g / aq. H₂O₂; NaOH / tetrahydrofuran / 2.5 h / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; dimethylsulfide borane complex; potassium tert-butylate; iodine; triphenylphosphine; In tetrahydrofuran; benzene; 3.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r